Furan based synthons are finding new uses in organic and polymer synthesis applications including the pharmaceutical, flavors & fragrances, graphic arts and organic intermediates industries.
Polysciences Inc. is pleased to announce a new family of furan derivatives including the difficult-to-find 3rd position substituted and disubstituted furans. Our unique boronic acid or halogen functional furan building blocks are appropriate for use in “Suzuki Synthesis” carbon-carbon bond forming reactions catalyzed by palladium.
A partial summary of materials is shown below. Materials available as standard stock without a 3 week lead time are shown with an (*).
furan*
For specialized derivatives of these or other furans, call us for a quotation!
References:
N. Miyaura and A. Suzuki, Chem. Rev., 95, 2457, 1995
A. Suzuki, Metal-catalyzed Cross Coupling Reactions, Wiley-VCH, 49-97(1988)
Y. Matsuya et. al. “Synthesis of a new class of furan fused tetracyclic compounds using o-quino dimethane chemistry and investigation of their anti-viral activity, J. Org. Chem., 69(23) 7989-93(2004)
J.A. Castro Hermida et.al.,”Anti Cryptosporidial activity of furan derivative G-1 and its inclusion complex with B-cyclodextrin,” J. Pharm. Sci., 93(1) 197-206 (2004)
R.W. Hemingway and A.H. Conner, The Chemistry of Furan Polymers,” in Adhesives from Renewable Resources, Oxford University Press, May 1989
T. Ruckle et. al. “Furan-2-yl methylene Thiazolidinediones as Novel, Potent, and Selective Inhibitors of Phosphoinositide 3 Kinase,” J. Med. Chem., 49(13)Z 3857-3871 (2006)
Henry N.C. Wong, “Regiospecific synthesis of polysubstituted furans and their application in Organic Synthesis,” Pure and Appl. Chem., 68, No. 2, 335-344(1996)
W.H. Miles, “Furan Approach to the Synthesis of the A-ring of Vitamin D Analogues,” Tetrahedron Letters, 44, 1161-1163(2003)
S. Kirschenbaum and M. Glantz, “2,3 diphenyl-1-indanone fluorometric analysis of Amino Acids,” Microchimica Acta, 65(6), 589-598 (1976)