PSVue® reagents are a family of fluorescent probes containing a bis(zinc2+dipicolylamine) group (Zn-DPA), a motif that has been found to bind with high affinity to surfaces enriched with anionic phospholipids,especially phosphatidylserine (PS) exposed on cell membranes. The fluorescent part of the probe is a reporter element that provides a means of detecting the probe once it is bound to the membrane of interest.
Key Features of PSVue® Probes:
- Bind to a variety of cell types which have negatively charged
phospholipids exposed on their membranes including apoptotic
cells [1], necrotic cells [2], Gram+ and Gram- bacteria [3-
5], activated cells, tumor vascular endothelial cells, viruses, etc.
- Available in a range of detection wavelengths from long-UV to
near infrared.
- Suitable for in vitro and in vivo use.
- Suitable for high-throughput screening assays.
- Bind to the same PS site as annexin-V.