Neuron specific enolase (NSE) is a unique form of the glycolytic enzyme enolase (E.C.188.8.131.52) found in neurons and in virtually all of the neuroendocrine, paraneuronal cell types. Certain neurological disorders are accompanied by increases in serum and spinal fluid NSE levels. NSE is also found in high concentrations in neuroendocrine tumors. Levels of NSE in biological fluids can be useful parameter for the assessment of neural tissue damage in the brain. Our human NSE and rat NSE have a specific activity of 40-60 units per mg. Both can be used in conjunction with anti-human NSE or anti-rat NSE to formulate an RIA to measure NSE levels in tissue, serum, or spinal fluid.
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