Polylactic Acid and Polyethylene Glycol Based Biodegradable Polymers

The exploration of polyethylene glycolated (PEG) materials in biosciences and pharmaceutics has grown rapidly. Biodegradable Polymers based on copolymers of polylactic acid (PLA) and polyethylene glycol (PEG) offer scientists new tools for controlled release formulations and delivery platforms.

The biodegradability of polymers based on lactic acid (LA) and its copolymers with ethylene glycol (EG) open new avenues for:

As well as offering the following advantages:

• Well defined release process
• Controlled degradation

Polymer structures featuring polyethylene glycol (PEG) segments with biodegradable or biocompatible segments offer micellular, nano and microsphere morphologies which are useful for controlled release formulations.

Diblock Polymers

Cat. No. 24375 - PEG(350)-b-PLA(300), Diblock Polymer

Cat. No. 24378 - PEG(1,000)-b-PLA(750), Diblock Polymer

Cat. No. 24381 - PEG(1,000)-b-PLA(5,000), Diblock Polymer

Cat. No. 24386 - PEG(5,000)-b-PLA(1,000), Diblock Polymer

Cat. No. 24389 - PEG(5,000)-b-PLA(5,000), Diblock Polymer

Cat. No. 25017 - PEG(10,000)-b-PLA(5,000), Diblock Polymer

Cat. No. 25018 - PEG(5,000)-b-PLA(10,000), Diblock Polymer

Triblock Polymers

Cat. No. 24500 - PLA(1,000)-b-PEG(1,000)-b-PLA(1,000), Triblock Polymer

Cat. No. 24501 - PLA(2,000)-b-PEG(1,000)-b-PLA(2,000), Triblock Polymer

Cat. No. 24502 - PLA(5,000)-b-PEG(1,000)-b-PLA(5,000), Triblock Polymer

Cat. No. 24503 - PLA(1,000)-b-PEG(4,000)-b-PLA(1,000), Triblock Polymer

Cat. No. 24509 - PLA(1,000)-b-PEG(10,000)-b-PLA(1,000), Triblock Polymer

Cat. No. 25026 - PLA(5,000)-b-PEG(10,000)-b-PLA(5,000), Triblock Polymer

Polysciences Inc. specializes in custom synthetic capabilities to modify or expand the range
of available materials.

We invite you to contact one of our technical specialists to discuss your specific needs regarding composition, specifications and supply by calling (800) 523-2575 / (215) 343-6484 or via [email protected]

References

1) Miyamoto, S.; etal, Polylactic acid-polyethylene glycol block copolymer. A new biodegradable synthetic carrier for bone morphogenetic protein. Clin Orthop Relat Res. 1993 Sep;(294):333-43.
2) Saito, N., etal, Synthetic biodegradable polymers as drug delivery systems for bone morphogenetic proteins. Adv Drug Deliv Rev. 2005 May 25;57(7):1037-48. Epub 2005 Apr 15. Review.
3) Liggins RT, Burt HM., Polyether-polyester diblock copolymers for the preparation of paclitaxel loaded polymeric micelle formations. Adv Drug Delivery Rev. 2002; 54:191-202.
4) Liu, L., etal, Biodegradable Polylactide/Poly(ethylene glycol)/Polylactide Triblock Copolymer Micelles as Anticancer Drug Carriers. Journal of Applied Polymer Science, Vol. 80, 1976–1982 (2001)
5) Kwon, G. D. Diblock copolymer nanoparticles for drug delivery. Crit Rev Ther Drug Carrier Syst. 1998; 15(5):481-512. Review.
6) Jeong B, etal., Biodegradable block copolymers as injectable drug-delivery systems. Nature, 1997; 388, 860-862.
7) Chang TM, etal., Analysis of polyethylene-glycol-polylactide nanodimension artificial red blood cells in maintaining systemic hemoglobin levels and prevention of methemoglobin formation. Artif Cells Blood Substit Immobil Biotechnol., 2003; Aug; 31, (3):231-47.