Heparan sulfate/heparin oligosaccharides

Heparan sulfate/heparin oligosaccharides

Homogeneous heparan sulfate/heparin oligosacchardies are difficult to obtain from natural sources or through chemical synthesis.  Using a chemoenzymatic method invented by Dr. Jian Liu at the University of North Carolina1, a range of oligosaccharides have been synthesized.  Heparan sulfate/heparin play essential roles in many biological processes, including blood coagulation, viral/bacterial infections tumor growth and embryonic development2. These heparan sulfate/heparin oligosaccharides are used to probe the structural selectivity in heparan sulfate-mediated biological functions. Polysciences’ heparan sulfate/heparin oligosaccharides are research reagents for cell biology, cancer, vascular biology, developmental biology, drug delivery, virology, glycomics/proteomics and pharmacology.


Catalog# Name Molecular Formula Size (µg)
25738 NA-4Mer GlcNAc-GlcA-GlcNAc-GlcA-pNP 1000
25739 NA-5Mer GlcA-GlcNAc-GlcA-GlcNAc-GlcA-pNP 1000
25740 NA-6Mer GlcNAc-GlcA-GlcNAc-GlcA-GlcNAc-GlcA-pNP 1000
25741 NA-7Mer GlcA-GlcNAc-GlcA-GlcNAc-GlcA-GlcNAc-GlcA-pNP 1000
25742 NA-8Mer GlcNAc-GlcA-GlcNAc-GlcA-GlcNAc-GlcA-GlcNAc-GlcA-pNP 1000
25743 NA-9Mer GlcA-GlcNAc-GlcA-GlcNAc-GlcA-GlcNAc-GlcA-GlcNAc-GlcA-pNP 1000
25744 NS-5Mer GlcNS-GlcA-GlcNS-GlcA-pNP 1000
25745 NS-6Mer GlcA-GlcNS-GlcA-GlcNS-GlcA-pNP 1000
25746 NS-7Mer GlcNS-GlcA-GlcNS-GlcA-GlcNS-GlcA-pNP 1000
25747 NS-8Mer GlcA-GlcNS-GlcA-GlcNS-GlcA-GlcNS-GlcA-pNP 1000
25748 NS-9Mer GlcNS-GlcA-GlcNS-GlcA-GlcNS-GlcA-GlcNS-GlcA-pNP 1000
25749 NS-9Mer Mono6S GlcA-GlcNS-GlcA-GlcNS-GlcA-GlcNS-GlcA-GlcNS-GlcA-pNP 1000
25750 NS-9Mer Di6S GlcA-GlcNS-GlcA-GlcNS-GlcA-GlcNS-GlcA-GlcNS6S-GlcA-pNP 500
25751 NS-9Mer Tri6S GlcA-GlcNS-GlcA-GlcNS-GlcA-GlcNS6S-GlcA-GlcNS6S-GlcA-pNP 500
25752 NS-9Mer Tetra 6S GlcA-GlcNS-GlcA-GlcNS6S-GlcA-GlcNS6S-GlcA-GlcNS6S-GlcA-pNP 500
25753 NS-8Mer Mono2S GlcA-GlcNS6S-GlcA-GlcNS6S-GlcA-GlcNS6S-GlcA-GlcNS6S-GlcA-pNP 500
25754 NS-8Mer Di2S GlcNS-GlcA-GlcNS-GlcA-GlcNS-IdoA2S-GlcNS-GlcA-pNP 250
25755 NA-8Mer Di2S GlcNS-GlcA-GlcNS-IdoA2S-GlcNS-IdoA2S-GlcNS-GlcA-pNP 250
25756 NA-8Mer Di2S GlcNAc-GlcA-GlcNS-IdoA2S-GlcNS-IdoA2S-GlcNS-GlcA-pNP 250
25757 NS6S-8Mer Mono 2S       GlcNS6S-GlcA-GlcNS6S-GlcA-GlcNS6S-IdoA2S-GlcNS6S-GlcA-pNP 250
25758 NS6S-8Mer Di2S GlcNS6S-GlcA-GlcNS6S-IdoA2S-GlcNS6S-IdoA2S-GlcNS6S-GlcA-pNP 100
25759 NA6S-8Mer Di2S GlcNAc6S-GlcA-GlcNS6S-IdoA2S-GlcNS6S-IdoA2S-GlcNS6S-GlcA-pNP 100
25760 3S-6Mer GlcNS6S-GlcA-GlcNS3S6S-IdoA2S-GlcNS6S-GlcA-pNP 100
25761 3SNA-8Mer GlcNAc6S-GlcA-GlcNS3S6S-IdoA2S-GlcNS6S-IdoA2S-GlcNS6S-GlcA-pNP 100

(1)    (a) Xu, Y.; Masuko, S.; Takieddin, M.; Xu, H.; Liu, R.; Jing, J.; Mousa, S. A.; Linhardt , R. J.; Liu, J. Science 2011, 334, 498(b) Xu, Y.; Cai, C.; Chandarajoti, K.; Hsieh, P.; Lin, Y.; Pham, T. Q.; Sparkenbaugh, E. M.; Sheng, J.; Key, N. S.; Pawlinski, R. L.; Harris, E. N.; Linhardt , R. J.; Liu, J. Nat Chem Biol 2014, 10, 248.

(2)    (a) Linhardt , R. J.; Liu, J. Curr Opin Pharmacol 2012, 12, 217(b) Shukla, D.; Spear, P. G. J. Clin. Invest. 2001, 108, 503(c) Bishop, J.; Schuksz, M.; Esko, J. D. Nature 2007, 446, 1030(d) Fuster, M. M.; Wang, L.; Castagnola, J.; Sikora, L.; Reddi, K.; Lee, P. H. A.; Radek, K. A.; Schuksz, M.; Bishop, J. R.; Gallo, R. L.; Sriramarao, P.; Esko, J. D. J. Cell Biol. 2007, 177, 539.

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