Filipin is highly fluorescent and binds specifically to cholesterol. It is widely used as a histochemical fluorescent stain for cholesterol. It is a polyene antifungal antibiotic produced naturally by the bacteria Streptomyces filipinensis.
Arthur, J. R., Heinecke, K. A. & Seyfried, T. N. Filipin recognizes both GM1 and cholesterol in GM1 gangliosidosis mouse brain. Journal of lipid research 52, 1345–51 (2011). doi:10.1194/jlr.M012633
Kruth, H. S., Cupp, J. E. & Khan, M. A. Method for detection and isolation of cholesteryl ester-containing ‘foam’ cells using flow cytometry. Cytometry 8, 146–152 (1987). doi:10.1002/cyto.990080207
, Skin sensitizer
- Glove, chemical goggles & fume hood
- Store at 4 degrees celsius