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Polycaprolactone, MW 50000, powder

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25090-100 100 g
$67.00
In Stock: 10
25090-500 500 g
$177.00
In Stock: 9
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Description

Polycaprolactone (PCL) is biodegradable polyester that is easy to manufacture, manipulate and blend. PCL can be used as an additive for resins to improve their processing characteristics and their end use properties. PCL adheres well to a large number of surfaces. It is easily fabricated, easily melted and is non-toxic. Additionally, PCL blends have been extensively studied to reduce cost and improve biodegradability by mixing with starch and other low cost organic fillers.

PLC as a bioresorbable polymer has received great deal of attention in use as a long term degradable implants as it can easily manipulated physically, chemically and biologically to suit a specific requirement. It is also studied as a scaffold for tissue repair via tissue engineering.

PCL is degraded by hydrolysis of its ester linkages under physiological conditions at much slower rate than polyglycolide (PGA), poly d,l-lactide (PDLA) and its copolymers. It was therefore originally used and FDA approved for long term drug-delivery devices and as slowly degrading suture materials.

Particle Size (< 600 µm): ≥ 98%

CAS#:
24980-41-4
Formula:

[-O(CH2)5CO-]n


Molecular Weight:
50,000
Melting Point:
58 – 60°C
Reference(s):

Aydin, O., Aydin, B., Tezcaner, A., & Keskin, D. Study on physiochemical structure and in vitro release behaviors of doxycycline-loaded PCL microspheres. Journal of Applied Polymer Science, 132(14) (2015). doi.org/10.1002/app.41768

Zhang, X., Zhang, Y., Liao, J., Yu, T., Hu, R., Wu, Z., & Wu, Q. Preparation and properties of compatible starch-polycaprolactone composites: Effects of molecular weight of soft segments in polyurethane compatilizer. Journal of Applied Polymer Science, 132(32) (2015). doi.org/10.1002/app.42381

Pohlmann, A. R., Fonseca, F. N., Paese, K., Detoni, C. B., Coradini, K., Beck, R. C., & Guterres, S. S. Poly(-caprolactone) microcapsules and nanocapsules in drug delivery. Expert Opinion on Drug Delivery, 10(5), 623–638 (2013). doi.org/10.1517/17425247.2013.769956

Zhang, Q., Luo, H., Zhang, Y., Zhou, Y., Ye, Z., Tan, W., & Lang, M. Fabrication of three-dimensional poly(epsilon-caprolactone) scaffolds with hierarchical pore structures for tissue engineering. Materials Science & Engineering. C, Materials for Biological Applications, 33(4), 2094–2103 (2013). doi.org/10.1016/j.msec.2013.01.025

Woodruff, M. A. & Hutmacher, D. W. The return of a forgotten polymer - Polycaprolactone in the 21st century. Progress in Polymer Science (Oxford) 35, 1217–1256 (2010). doi:10.1016/j.progpolymsci.2010.04.002

Tokiwa, Y., Calabia, B. P., Ugwu, C. U., & Aiba, S. Biodegradability of Plastics. International Journal of Molecular Sciences, 10(9), 3722–3742 (2009). doi.org/10.3390/ijms10093722


TSCA
 
Hazards:
Irritant
Handling:
Gloves & chemical goggles
Storage:
Store at room temperature

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