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Lowicryl® K4M Polar, Hydrophilic, -35ºC embedding kit

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Catalog No. Packaging Size Price Quantity
15923-1 1 kit
€527.00

Description

Lowicryls are low viscosity, highly cross-linked acrylate and methacrylate based embedding media.  They are designed to preserve molecular structure/antigens by being applied at low temperatures. Because they preserve antigenicity, Lowicryls are a useful alternative to epoxy resins in immunochemistry.

Lowicryl® K kits are polar and hydrophilic and have many advantages over other methods. During dehydration and infiltration specimens may be kept partially hydrated and polymerized with up to 5% water. They are also useful in immunolabeling of sections using specific antisera, lectins and colloidal gold particles.

Lowicryl® K4M kit can be used for tissue infiltration and polymerization at temperature as low as −35ºC. The use of K4M results in better structural/antigen preservation and lower background labeling compared to other methods.

Kit contains: 1x130gm of Crosslinker A, 3x250gm of Monomer B, and 2x4.8gm of Initiator C

Reference(s):

Dittmann C, Han HM, Grabenbauer M, Laue M. (2015). Dormant Bacillus spores protect their DNA in crystalline nucleoids against environmental stress. J Struct Biol. 191(2):156-64. 

Newman GR, Hobot JA. (1999). Resins for combined light and electron microscopy: a half century of development. Histochem J. 31(8):495-505.

Roth J, Taatjes DJ, Tokuyasu KT. (1990). Contrasting of Lowicryl K4M thin sections. Histochemistry 95(2):123–136.

Altman LG, Schneider BG, Papermaster DS. (1984). Rapid embedding of tissues in Lowicryl K4M for immunoelectron microscopy. J Histochem Cytochem. 32(11):1217-23.


TSCA
 
Hazards:
Irritant, Lachrymator, Poison (Absorption)
Handling:
Glove, chemical goggles & chemical mask or hood
Storage:
Protect from light;Store at room temperature
Code:
HIR7ag - (hazard/handling/storage codes)

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