Poly(N-isopropylacrylamide) (PNiPAM)
Polymer is water-soluble at room temperature, insoluble above ~40º. Solubility ceiling has been used in mold and cell growth techniques since cells adhere to polymer film at incubation temperatures and are released as medium is cooled and polymer is dissolved.
Synonyms: PNIPAM; Poly(N-isopropylacrylamide); PolyNIPAAm; NIPAM polymerNuopponen, M., Ojala, J. & Tenhu, H. Aggregation behaviour of well defined amphiphilic diblock copolymers with poly(N-isopropylacrylamide) and hydrophobic blocks. Polymer 45, 3643–3650 (2004). doi:10.1016/j.polymer.2004.03.083
Zhang, J. & Peppas, N. A. Synthesis and Characterization of pH- and Temperature-Sensitive Poly(methacrylic acid)/Poly( N -isopropylacrylamide) Interpenetrating Polymeric Networks. Macromolecules 33, 102–107 (2000). doi:10.1021/ma991398q
Feil, H., Bae, Y. H., Feijen, J. & Kim, S. W. Effect of comonomer hydrophilicity and ionization on the lower critical solution temperature of N-isopropylacrylamide copolymers. Macromolecules 26, 2496–2500 (1993). doi:10.1021/ma00062a016
