Poly(D,L-lactide-co-glycolide), 50:50, IV 0.4 dl/g, acid-terminated
Poly(DL-lactide-co-glycolide) (PLGA) is a well-established biodegradable polymer used in medical devices and drug delivery applications. In comparison to poly(L-lactide) (PLLA), PLGA offers control over degredation rate and reduced glass transition temperatures (by increasing glycolide content).1 The control of these properties makes PLGA especially well suited for applications where medical devices are only needed for weeks (e.g. drug
Acid-terminated PLGA allows for easy conjugation to drugs with nucleophilic functionalities.4
Synonyms: PDLGA, PLGA, DL-PLGA
1. Middleton, John C., and Arthur J. Tipton. 2000. "Synthetic Biodegradable Polymers as Orthopedic Devices.” Biomaterials 21 (23): 2335–46. doi:10.1016/S0142-9612(00)00101-0.
2. Grayson, Amy C Richards, Insung S Choi, Betty M Tyler, Paul P Wang, Henry Brem, Michael J Cima, and Robert Langer. 2003. “Multi-Pulse Drug Delivery from a Resorbable Polymeric Microchip Device.” Nature Materials 2 (11). Nature Publishing Group: 767–72. doi:10.1038/nmat998.
3. Dawes, G J S, L E Fratila-Apachitei, K Mulia, I Apachitei, G-J Witkamp, and J Duszczyk. 2009. “Size Effect of PLGA Spheres on Drug Loading Efficiency and Release Profiles.” Journal of Materials Science: Materials in Medicine 20 (5). Springer: 1089–94. doi:10.1007/s10856-008-3666-0.
4. Crucho, Carina I C, and Maria Teresa Barros. 2015. “Formulation of Functionalized PLGA Polymeric Nanoparticles for Targeted Drug Delivery.” Polymer 68 (June): 41–46. doi:http://dx.doi.org/10.1016/j.polymer.2015.04.083.
SPECIFICATIONS
FTIR: conforms Inherent Viscosity (ηinh): 0.30 - 0.50 dL/g (25°C; CHCl3; 0.5 g/dL) Acid Number: ≥ 3 (mg KOH)/g Lactide/Glycolide : 45-55/45-55 (mol%) (NMR)
PROPERTIES
Viscosity Molecular Weight (Mη): 22,000 - 45,000 Glass Transition Temp. (Tg): 45-50°C 1 Soluble in: dichloromethane (DCM), tetrahydrofuran (THF), ethyl acetate, acetone
