Linear polyethylenimine (PEI 2500) is a high-charge cationic polymer that readily binds highly anionic substrates. Industrially, linear PEI can improve the appearance of negatively charged dyes by modulating their properties and improving their adherence to surfaces. In research, PEI readily binds to DNA and other negatively charged biological molecules, making it one of the most efficient vector carriers available.
Product contains 7-11% of the acylated amine (N-propionylated) from isomerization-polymerization of 2-ethyl-2-oxazoline followed by acid-hydrolysis of resulting N-propionyl-PEI. For fully deacylated PEI, see Polyethylenimine HCl MAX, Linear, Mw 4,000 (PEI MAX 4000; Catalog # 24885)
See Transporter™ 5 Transfection Reagent for our ready-to-use PEI derivative.
- 9002-98-6, 26913-06-4
- Molecular Weight:
- Melting Point:
- Soluble In:
- hot water, cold water at low pH, methanol, and ethanol
Insoluble In: Benzene, ethyl ether, acetone, and cold water.
- Tan to brown solid
Siegman S, Truong NF, Segura T. (2015). Encapsulation of PEGylated low-molecular-weight PEI polyplexes in hyaluronic acid hydrogels reduces aggregation. Acta Biomater. in Press, doi:10.1016/j.actbio.2015.09.020
Liu X, Heiler DJ. (2010). Contact Lens Care Solutions with a Low Molecular Weight Oligomer." U.S. Patent 20,100,086,514, issued April 8, 2010.
Thomas M, Lu JJ, Ge Q, Zhang C, Chen J, Klibanov AM. (2005).Full deacylation of polyethylenimine dramatically boosts its gene delivery efficiency and specificity to mouse lung. Proc Natl Acad Sci U S A. 102(16):5679-84.
- Irritant, Unknown
- Gloves & chemical goggles
- Store at room temperature