DOSPA Chloride
C54H115CI5N6O3
DOSPA Chloride is a widely used cationic lipid used in the formation of Lipid Nanoparticles (LNP) or Nanostructured Lipid carriers (NLCs) in the development of mRNA vaccines such as COVID-19 vaccine. LNPs facilitate the safe and effective delivery of mRNA to target cells, therefore enabling therapeutic action. Polysciences’ high purity, transfection grade DOSPA Chloride can be used in conjunction with our other cationic lipid products to provide reliable performance for bioprocessing applications. This product is for research use only. Contact us at [email protected] to know about our cGMP grade manufactured DOSPA Chloride under 21 CFR part 210,211.
Key Features:
- High efficiency
- Reproducibility
- Cost effective
- Easy-to-use
Hofland, H., Shepard, L., & Sullivan, S. (1996). Formation of stable cationic lipid/DNA complexes for gene transfer. Proc. Natl. Acad. Sci. USA. 93: 7305-7309.
Swaney, W., Sorgi, F., Bahnson, A., & Barranger, J. (1997). The effect of cationic liposome pretreatment and centrifugation on retrovirus-mediated gene transfer. Gene Therapy. 4: 1379-1386.
Vieweg, J., Boczkowski, D., Roberson, K., Edwards, D., Philip, M., Philip, R., Rudoll, T., Smith, C., Roberson, C., & Gilboa, E. (1995). Efficient Gene Transfer with Adeno-associated Virus-based Plasmids Complexed to Cationic Liposomes for Gene Therapy of Human Prostate Cancer. Cancer Research. 55: 2366-2372.
