DODMA (1,2-dioleyloxy-3-dimethylaminopropane) is an ionizable cationic lipid with a protonatable tertiary amine head group that shows positive charge at low pH. DODMA is highly efficient at encapsulating nucleic acid to form lipoplexes during synthesis by reducing the physiological pH, which readily passes through the cell membrane. These properties make DODMA highly suitable for transfection and drug delivery applications.
- Efficient delivery of plasmid DNA, siRNA/miRNA and CRISPR/Cas9 components
- Cost effective
- Flexibility and reproducibility
Contact us at [email protected] to know about our cGMP grade DODMA manufactured under 21 CFR part 210,211.
Patel, S., Ryals, C., Weller, K., Pennesi, M.,, Sahay, G. (2019) Lipid nanoparticles for delivery of messenger RNA to the back of the eye. J Control Release. 12;303:91-100.
Heyes, J., Palmer, L., Bremner, K., & MacLachlan, I. (2005). Cationic lipid saturation influences intracellular delivery of encapsulated nucleic acids. Journal of Controlled Release 107(2) 276-287.
Hsu, S., Yu, B., Wang, X., Lu, Y., Schmidt, C., Lee, R., Lee, J., Jacob, S., & Ghoshal, K. (2013). Cationic lipid nanoparticles for therapeutic delivery of siRNA and miRNA to murine liver tumor. Nanomedicine. 9(8): 1169-1180.
Zhou, C., Zhang, A., Yang, Z., Wang, X., Chang, L., Chen, Z., & Ly, J. (2016) Application of DODMA and Derivatives in Cationic Nanocarriers for Gene Delivery. Current Organic Chemistry 20(17): 1813-1819.