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DODMA (1,2-dioleyloxy-3-dimethylaminopropane)

DODMA (1,2 - dioleyloxy - 3 - dimethylaminopropane) - Polysciences

DODMA (1,2 - dioleyloxy - 3 - dimethylaminopropane) - Polysciences

Product Number:

CAS #

14478

104162-47-2

Product #

CAS #

14478

104162-47-2

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Product Specifications

No Product Specifications

Safety Data Sheet (SDS)

Related Documents

No Related Documents

References

Patel, S., Ryals, C., Weller, K., Pennesi, M.,, Sahay, G. (2019) Lipid nanoparticles for delivery of messenger RNA to the back of the eye. J Control Release. 12;303:91-100.

Heyes, J., Palmer, L., Bremner, K., & MacLachlan, I. (2005). Cationic lipid saturation influences intracellular delivery of encapsulated nucleic acids. Journal of Controlled Release 107(2) 276-287.

Hsu, S., Yu, B., Wang, X., Lu, Y., Schmidt, C., Lee, R., Lee, J., Jacob, S., & Ghoshal, K. (2013). Cationic lipid nanoparticles for therapeutic delivery of siRNA and miRNA to murine liver tumor. Nanomedicine. 9(8): 1169-1180.

Zhou, C., Zhang, A., Yang, Z., Wang, X., Chang, L., Chen, Z., & Ly, J. (2016) Application of DODMA and Derivatives in Cationic Nanocarriers for Gene Delivery. Current Organic Chemistry 20(17): 1813-1819.

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Product Description

DODMA (1,2-dioleyloxy-3-dimethylaminopropane) is an ionizable cationic lipid with a protonatable tertiary amine head group that shows positive charge at low pH. DODMA is highly efficient at encapsulating nucleic acid to form lipoplexes during synthesis by reducing the physiological pH, which readily passes through the cell membrane. These properties make DODMA highly suitable for transfection and drug delivery applications.
Key Features

Efficient delivery of plasmid DNA, siRNA/miRNA and CRISPR/Cas9 components
Cost effective
Flexibility and reproducibility

Synonym: 1,2-Dioleyloxy-3-dimethylaminopropane

DODMA (1,2 - dioleyloxy - 3 - dimethylaminopropane) - Polysciences

DODMA (1,2 - dioleyloxy - 3 - dimethylaminopropane) - Polysciences

Product Specifications

No Product Specifications

Linear Formula

C41H81NO2

Appearance

Colorless to light yellow liquid

Application

DNA, SiRNA, mRNA transfection, Drug delivery, Gene therapy

Safety Data Sheet (SDS)

-20°C

Related Documents

References

Patel, S., Ryals, C., Weller, K., Pennesi, M.,, Sahay, G. (2019) Lipid nanoparticles for delivery of messenger RNA to the back of the eye. J Control Release. 12;303:91-100.

Heyes, J., Palmer, L., Bremner, K., & MacLachlan, I. (2005). Cationic lipid saturation influences intracellular delivery of encapsulated nucleic acids. Journal of Controlled Release 107(2) 276-287.

Hsu, S., Yu, B., Wang, X., Lu, Y., Schmidt, C., Lee, R., Lee, J., Jacob, S., & Ghoshal, K. (2013). Cationic lipid nanoparticles for therapeutic delivery of siRNA and miRNA to murine liver tumor. Nanomedicine. 9(8): 1169-1180.

Zhou, C., Zhang, A., Yang, Z., Wang, X., Chang, L., Chen, Z., & Ly, J. (2016) Application of DODMA and Derivatives in Cationic Nanocarriers for Gene Delivery. Current Organic Chemistry 20(17): 1813-1819.