PLGA(50:50)(50,000)-b-mPEG (4,000), Diblock polymer, Powder

PLGA(50:50)(50,000) - b - mPEG (4,000), Diblock polymer, Powder - Polysciences
PLGA(50:50)(50,000) - b - mPEG (4,000), Diblock polymer, Powder - Polysciences

Product Number:

    50348

Size

Price

$324.36

Quantity

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Product Specifications
Safety Data Sheet (SDS)
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References

    1. Panagi, Z., Beletsi, A., Evangelatos, G., Livaniou, E., Ithakissios, D. S., & Avgoustakis, K. (2001). Effect of dose on the biodistribution and pharmacokinetics of PLGA and PLGA–mPEG nanoparticles. International journal of pharmaceutics, 221(1-2), 143-152.

    2. Cheng, L., Jin, C., Lv, W., Ding, Q., & Han, X. (2011). Developing a highly stable PLGA-mPEG nanoparticle loaded with cisplatin for chemotherapy of ovarian cancer. PloS one, 6(9), e25433.

    3. Ashjari, M., Panahandeh, F., Niazi, Z., & Abolhasani, M. M. (2020). Synthesis of PLGA–mPEG star-like block copolymer to form micelle loaded magnetite as a nanocarrier for hydrophobic anticancer drug. Journal of Drug Delivery Science and Technology, 56, 101563.

    4. Shen, X., Li, T., Xie, X., Feng, Y., Chen, Z., Yang, H., ... & Liu, Y. (2020). PLGA-based drug delivery systems for remotely triggered cancer therapeutic and diagnostic applications. Frontiers in Bioengineering and Biotechnology, 8, 381.

    5. Rocha, C. V., Gonçalves, V., da Silva, M. C., Bañobre-López, M., & Gallo, J. (2022). PLGA-based composites for various biomedical applications. International Journal of Molecular Sciences, 23(4), 2034.

Product Description

PLGA(50:50)(50,000)-b-mPEG (4,000), Diblock polymer, Powder

Diblock copolymer | Powder (micronized)

Product Description

Poly(lactic-co-glycolic acid)-block-polyethylene glycol (PLGA-b-mPEG) is a high-grade, biodegradable, amphiphilic diblock copolymer supplied as a micronized powder and suitable for biomedical research applications. This material consists of a PLGA block with a 50:50 lactic acid:glycolic acid ratio and a molecular weight of approximately 50,000, covalently linked to methoxy-terminated polyethylene glycol (mPEG) with a molecular weight of approximately 4,000.

The copolymer combines the controlled hydrolytic degradation of PLGA with the hydrophilicity and biocompatibility of PEG. The PEG block increases aqueous compatibility and influences surface properties, while the PLGA segment governs degradation behavior and mechanical integrity. Variation in PLGA composition and block molecular weights allows modulation of degradation rate, amphiphilicity, and hydrophilic–lipophilic balance, enabling tailored performance in drug delivery and biomaterials research.

Due to its amphiphilic structure, PLGA-b-mPEG can self-assemble in aqueous environments and is widely studied for nanoparticle, micelle, and hydrogel systems intended for controlled drug encapsulation and release.

Key Properties

  • Polymer type: PLGA-b-mPEG diblock copolymer
  • PLGA composition: 50:50 (lactic acid:glycolic acid)
  • PLGA molecular weight: ~50,000
  • PEG type: Methoxy-polyethylene glycol (mPEG)
  • PEG molecular weight: ~4,000
  • Architecture: Amphiphilic diblock copolymer
  • Form: Powder (micronized)
  • Biodegradability: Hydrolytically degradable PLGA block
  • Typical use: Biomedical and pharmaceutical research

Applications

PLGA(50:50)-b-mPEG diblock copolymers are widely used in biomedical and pharmaceutical research, particularly in systems requiring controlled degradation and improved aqueous compatibility, including:

  • Drug delivery systems (polymeric nanoparticles, micelles, controlled-release matrices)
  • Encapsulation of hydrophobic therapeutics
  • Cancer therapeutics research
  • Hydrogel and injectable formulation development
  • Tissue engineering and bioactive scaffolds
  • Surface-modified and “stealth” biomaterial studies

Synonyms / Acronyms

  • PLGA-b-mPEG
  • PLGA-mPEG

FAQs

Common questions about PLGA(50:50)(50,000)-b-mPEG (4,000).

  • What is PLGA-b-mPEG?

    PLGA-b-mPEG is an amphiphilic diblock copolymer made by covalently linking a PLGA block to a methoxy-terminated PEG (mPEG) block. The PLGA segment is biodegradable, while the PEG segment increases hydrophilicity and can influence surface properties.

  • What does “PLGA(50:50)(50,000)-b-mPEG (4,000)” mean?

    It indicates a PLGA block with a 50:50 lactic acid:glycolic acid ratio and an approximate molecular weight of 50,000, linked to an mPEG block with an approximate molecular weight of 4,000.

  • Why is PLGA-b-mPEG considered amphiphilic?

    The PLGA block is relatively hydrophobic, while PEG is hydrophilic. This combination can promote self-assembly in aqueous environments (for example, into micelles or nanoparticles), depending on concentration and formulation conditions.

  • What is the role of the PEG (mPEG) block in drug delivery research?

    The PEG block can increase aqueous compatibility and influence particle surface behavior. In many research contexts, PEGylated surfaces are studied for reduced non-specific interactions and improved stability, although outcomes depend on formulation and test conditions.

  • How can block molecular weights and composition affect performance?

    Changing the PLGA composition (lactide:glycolide ratio) and the PLGA/PEG block molecular weights can influence degradation behavior, amphiphilicity, and the hydrophilic–lipophilic balance. These parameters are commonly adjusted to tune self-assembly and release behavior in research formulations.

  • Why use a micronized powder form?

    Micronized powders can support more uniform blending and dissolution/dispersion steps in processing workflows and may improve handling consistency for research formulations.

PLGA(50:50)(50,000) - b - mPEG (4,000), Diblock polymer, Powder - Polysciences
PLGA(50:50)(50,000) - b - mPEG (4,000), Diblock polymer, Powder - Polysciences
Product Specifications
Linear Formula
    [C3H4O2]m[C2H2O2]n[C2H4O]x 
Appearance
    White to off-white to light tan powder
Biodegradation Time
    Months
Safety Data Sheet (SDS)
Handling
    Gloves & fume hood
Storage
    Protect from moisture. Store at -20°C.
Hazards
    Harmless - use normal precautions; Hygroscopic
Related Documents

    No Related Documents

References

    1. Panagi, Z., Beletsi, A., Evangelatos, G., Livaniou, E., Ithakissios, D. S., & Avgoustakis, K. (2001). Effect of dose on the biodistribution and pharmacokinetics of PLGA and PLGA–mPEG nanoparticles. International journal of pharmaceutics, 221(1-2), 143-152.

    2. Cheng, L., Jin, C., Lv, W., Ding, Q., & Han, X. (2011). Developing a highly stable PLGA-mPEG nanoparticle loaded with cisplatin for chemotherapy of ovarian cancer. PloS one, 6(9), e25433.

    3. Ashjari, M., Panahandeh, F., Niazi, Z., & Abolhasani, M. M. (2020). Synthesis of PLGA–mPEG star-like block copolymer to form micelle loaded magnetite as a nanocarrier for hydrophobic anticancer drug. Journal of Drug Delivery Science and Technology, 56, 101563.

    4. Shen, X., Li, T., Xie, X., Feng, Y., Chen, Z., Yang, H., ... & Liu, Y. (2020). PLGA-based drug delivery systems for remotely triggered cancer therapeutic and diagnostic applications. Frontiers in Bioengineering and Biotechnology, 8, 381.

    5. Rocha, C. V., Gonçalves, V., da Silva, M. C., Bañobre-López, M., & Gallo, J. (2022). PLGA-based composites for various biomedical applications. International Journal of Molecular Sciences, 23(4), 2034.