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DOTAP Chloride

CAS Number:

132172-61-3

Linear Formula:

C₄₂H₈₀ClNO₄

Grouped product items
Catalog Number	Unit Size	Price
14475-25	25mg	€0.00
14475-100	100mg	€0.00
14475-500	500mg	€0.00

To purchase this item please go to Kyfora Bio
www.kyforabio.com

In stock

Product Overview

DOTAP Chloride (N-[1-(2,3-Dioleoyloxy)propyl]-N,N,N-trimethylammonium chloride) is a widely used cationic liposome-forming compound for in vitro and in vivo transfection of DNA, RNA and other negatively charged molecules. DOTAP encapsulates the nucleic acids to form a stable complex spontaneously by means of electrostatic interaction, facilitates cell attachment, internalization by endocytosis as well as endosomal escape by proton sponge. It has been used in the formation of Lipid Nanoparticles (LNPs) or Nanostructured Lipid carriers (NLCs) in the development of mRNA vaccines such as COVID-19 vaccine and drug delivery systems. This product is for research use only.

Key features:

High efficiency and reproducibility
Cost effective and easy to use
Scalable

Application(s):

Transfection of DNA, RNA, and oligonucleotides, Lipid Nanoparticles (LNPs), Nanostructured Lipid Carriers (NLCs), mRNA vaccine development, Drug delivery system development

Shipping Requirements:

Dry Ice

Properties

Appearance:

White to off white solid

Molecular Weight:

698.54

References

Jain S, Kumar S, Agrawal AK, Thanki K, Banerjee UC. Enhanced transfection efficiency and reduced cytotoxicity of novel lipid-polymer hybrid nanoplexes. Mol Pharm. 2013;10(6):2416-2425. doi:10.1021/mp400036w

Simberg, Dmitri, et al. "DOTAP (and other cationic lipids): chemistry, biophysics, and transfection." Critical Reviews™ in Therapeutic Drug Carrier Systems 21.4 (2004).

Safety & Storage

Storage:

Store powdered material at -20°C, protect from moisture and light.