Lipids for Nanodelivery Systems
  1. DOTAP Chloride
    DOTAP Chloride
    Catalog Number 14475

    DOTAP Chloride (N-[1-(2,3-Dioleoyloxy)propyl]-N,N,N-trimethylammonium chloride) is a widely used cationic liposome-forming compound for in vitro and in vivo transfection of DNA, RNA and other negatively charged molecules.

     

  2. DOTMA Chloride
    DOTMA Chloride
    Catalog Number 14476

    DOTMA Chloride (N-[1-(2,3-Dioleyloxy)propyl]-N,N,N-trimethylammonium (chloride)) is a proven reagent for the highly efficient liposomal transfection of DNA, RNA, oligonucleotides, and other negatively charged large biomolecules.

  3. DODMA (1,2-dioleyloxy-3-dimethylaminopropane)
    DODMA (1,2-dioleyloxy-3-dimethylaminopropane) is an ionizable cationic lipid with a protonatable tertiary amine head group that shows positive charge at low pH. DODMA is highly efficient at encapsulating nucleic acid to form lipoplexes during synthesis by reducing the physiological pH, which readily passes through the cell membrane. These properties make DODMA highly suitable for transfection and drug delivery applications.
  4. DODAP (1,2-dioleoyl-3-dimethylammonium propane)

    Ionizable Cationic Liposomal Transfection Reagent

  5. DOSPA Chloride
    DOSPA Chloride
    Catalog Number 14477

    DOSPA Chloride is a widely used cationic lipid used in the formation of Lipid Nanoparticles (LNP) or Nanostructured Lipid carriers (NLCs) in the development of mRNA vaccines such as COVID-19 vaccine. 

  6. DSTAP Chloride (1,2-distearoyl-3-trimethylammonium-propane chloride)
    Cationic lipid that can be used as an effective transfection reagent in a variety of cell lines/cell types grown in suspension and adherent cultures.
  7. DMTAP (1,2-dimyristoyl-3-trimethylammonium-propane chloride)
    Saturated cationic lipid with applications in transfection and drug delivery.
  8. DPTAP (1,2-dipalmitoyl-3-trimethylammonium-propane chloride)

    Cationic lipid that can be used as an effective transfection reagent in a variety of cell lines/cell types grown in suspension and adherent cultures.

  9. Cholesterol
    Cholesterol
    Catalog Number 26436

    Cholesterol is a naturally occurring sterol lipid that is a receiving growing emphasis in the bioprocessing space for its ability to improve DNA transfection efficiency by reducing the adherence of serum proteins to lipopolyplexes and increasing fusion with cellular membranes.

  10. Distearoylphosphatidylcholine (DSPC)

    Distearoylphosphatidylcholine (DSPC) is a zwitterionic phospholipid that is used in the preparation of liposomes for transfection and drug delivery applications. DSPC functions to enhance encapsulation efficiency and liposome stability which enables greater effectiveness in bioprocessing.

  11. ALC-0159
    ALC-0159
    Catalog Number 14492

    ALC-0159 (N,N-dimyristylamide of 2-hydroxyacetic acid) is a widely used liposome-forming compound for in vitro and in vivo transfection of DNA, RNA and other negatively charged molecules.

  12. DMG-PEG2000
    DMG-PEG2000
    Catalog Number 14493

    DMG-PEG2000 (1,2-dimyristoyl-rac-glycero-3-methoxypolyethylene glycol-2000) is a widely used liposome-forming compound for in vitro and in vivo transfection of DNA, RNA and other negatively charged molecules.

  13. DLin-MC3-DMA
    DLin-MC3-DMA
    Catalog Number 14496

    DLin-MC3-DMA is an ionizable cationic lipid used for gene delivery in vivo.

  14. DMPC
    DMPC
    Catalog Number 26447

    DMPC is a zwitterionic phospholipids used to formulate liposomes, lipid nanoparticles, and other related nanodelivery systems for gene delivery.

  15. DPPC
    DPPC
    Catalog Number 26449

    DPPC is an amphipathic phospholipid used for gene and drug delivery formulations. 

  16. DOPC
    DOPC
    Catalog Number 26450

    DOPC is a neutral helper lipid used in gene and drug delivery liposomal formulations.

  17. DOPE
    DOPE
    Catalog Number 26451

    DOPE is a neutral helper lipid used in gene and drug delivery liposomal formulations.

  18. DSPE
    DSPE
    Catalog Number 26452

    DSPE, a saturated zwitterionic phospholipid and a derivative of phosphatidylethanolamine, can be used in liposomal drug and gene delivery formulations. 

  19. DSPG, Sodium Salt
    DSPG, Sodium Salt
    Catalog Number 26453

    DSPG is an anionic phospholipid in liposomal drug and gene delivery formulations.

  20. Beta-sitosterol
    Beta-sitosterol
    Catalog Number 14495

    Beta-sitosterol is a naturally occurring sterol lipid that is growing in the bioprocessing space for its ability to improve mRNA transfection efficiency.

  21. Palmitic Acid
    Palmitic Acid
    Catalog Number 14501

    Palmitic acid is a naturally occurring saturated fatty acid that has been shown to have high transfection efficiency for the delivery of plasmids and mRNA in a variety of cell types.

  22. Octanoic Acid
    Octanoic Acid
    Catalog Number 14504
    Octanoic acid, also known as caprylic acid, is a medium chain saturated fatty acid that can be used to formulate self-emulsifying drug delivery systems (SEDDS) that significantly improve the bioavailability of drugs.
  23. Hydrogenated Soybean Phosphatidylcholine (HSPC)

    Hydrogenated Soybean Phosphatidylcholine (HSPC) is a saturated phospholipid used in liposomal drug delivery formulations.

  24. Stearic Acid
    Stearic Acid
    Catalog Number 14500

    Stearic acid is a saturated fatty acid used to formulate solid lipid nanoparticles (SLNs).

  25. Dimethyldioctadecylammonium (Bromide Salt)

    DDAB is a synthetic amphiphilic cationic lipid adjuvant that can be used to induce cell-mediated and humoral responses. 

  26. Stigmasterol
    Stigmasterol
    Catalog Number 14497

    Stigmasterol is a naturally occurring phytosterol lipid that is growing in the bioprocessing space for its ability to improve lipid nanoparticle (LNP)-based mRNA transfection efficiency.

  27. β-Sitosteryl hemisuccinate (β-STEMS)

    β-Sitosteryl hemisuccinate is a β-sitosterol derivative that has been shown to have cholesterol lowering effects.

  28. Cholesteryl Hemisuccinate (CHEMS)

    Cholesteryl hemisuccinate (CHEMS) is a cholesterol derivate that is responsive to changes in pH.

  29. Stigmasteryl hemisuccinate (STEMS)

    Stigmasteryl hemisuccinate (STEMS) is a stigmasterol derivative that is responsive to changes in pH.

  30. desmosterol
    desmosterol
    Catalog Number 14522
    Desmosterol is a sterol lipid with a backbone similar to cholesterol. It is the precursor to cholesterol in the Bloch biosynthesis pathway. It is known to be a regulator of lipid metabolism.
  31. lathosterol
    lathosterol
    Catalog Number 14523
    Lathosterol is a precursor in the cholesterol synthesis pathway. Lathosterol can be used as a biomarker of excess cholesterol production as lathosterol levels in serum corresponds with cholesterol synthesis.
  32. sitostanol
    sitostanol
    Catalog Number 14524
    Sitostanol is a saturated plant sterol that can be used to lower serum cholesterol.
  33. Brassicasterol
    Brassicasterol
    Catalog Number 14525
    Brassicasterol is a phytosterol that can be used as a biomarker to detect the presence of marine algal matter.
  34. Fucosterol
    Fucosterol
    Catalog Number 14510
    Fucosterol is a plant sterol that has antioxidant and antiinflammatory properties. Inclusion of fucosterol in lipid nanoparticle (LNP) formulations has been shown to increase transfection efficiency rates both in cell cultures and in vivo, leading to particular interest in the use of the lipid in mRNA vaccine development.
  35. Campesterol
    Campesterol
    Catalog Number 14511
    Campesterol is a phytosterol and an agonist of liver X receptors, which are involved in the transcriptional control of lipid metabolism. Inclusion of campesterol in lipid nanoparticle (LNP) formulations has been shown to increase transfection efficiency rates both in cell cultures and in vivo, leading to particular interest in the use of the lipid in mRNA vaccine development.
  36. BODIPY-Cholesterol
    BODIPY-Cholesterol
    Catalog Number 14526
    Bodipy-Cholesterol is cholesterol tagged with the fluorophore BODIPY. It can be used to monitor uptake in LNP uptake in cells. It has an ex/em of 480 nm/508 nm.
  37. DSPE PEG 2000, Amine
    DSPE PEG 2000, Amine
    Catalog Number 14499
    DSPE-PEG(2000)-amine is DSPE (a phospholipid) functionalized with PEG2000. DSPE-PEG2000 can be used in LNPs for mRNA delivery.
  38. Tristearin
    Tristearin
    Catalog Number 14527
    Tristearin is a lipid used in the development of solid lipid nanoparticles (SLNs). SLNs are advantageous due to their high stability, biocompatibility, and enhanced circulation of encapsulated therapeutic payload. Stearic acid, when combined with a surfactant, can be used to formulate SLNs to improve drug efficacy.
  39. 7-dehydrocholesterol (high purity)
    7-dehydrocholesterol is an immediate precursor of cholesterol in the cholesterol biosynthesis pathway. It is also a provitamin that is converted to vitamin D3 by UVB light.
  40. Cholesterol Sulfate
    Cholesterol Sulfate
    Catalog Number 14535
    Cholesterol sulfate (sodium salt) is found in cell membranes. It affects lipid metabolism, stabilizes the cell membrane, and acts as a substrate for steroid synthesis. It can be used in the development of liposomes when studying the properties of cell membranes.
  41. 8-dehydro cholesterol
    8-dehydro cholesterol
    Catalog Number 14536
    8-dehydro cholesterol is an isomer of an immediate precursor of cholesterol (7-DHC) in the cholesterol biosynthesis pathway.
  42. Dehydroepiandrosterone (DHEA)
    DHEA is an endogenous steroid secreted by the adrenal gland. It is known to modulate a variety of cellular and nuclear receptors.
  43. Diosgenin
    Diosgenin
    Catalog Number 14538
    Diosgenin is a natural steroid that has anti-inflammatory, hypoglycemic, and pro-apoptotic properties.
  44. Tricosanoic Acid
    Tricosanoic Acid
    Catalog Number 14540
    Tricosanoic Acid is a polyunsaturated fatty acid known to have tumor-supressing activity.
  45. ALC-0315
    ALC-0315
    Catalog Number 14491
    ALC-0315 is an ionizable lipid used for mRNA delivery to cells. It can be used to formulate lipid nanoparticles, like those used in the COVID-19 vaccine.
  46. Dimethyldimyristylammonium Bromide
    Dimethyldimyristylammonium Bromide is a cationic lipid used in combination with other lipids to formulate lipid nanoparticles.
  47. DLinDMA
    DLinDMA
    Catalog Number 14546
    DLinDMA is an ionizable amino lipid that can be used with other lipids to formulate lipid nanoparticles.
  48. N-nitrophenyl palmitate
    N-nitrophenyl palmitate
    Catalog Number 14547
    N-nitrophenyl palmitate is a colorimetric lipase that can be used to measure enzyme activity. Upon enzymatic hydrolysis, 4-nitrophenol is released which can be quantified using colorimetric detection at 410 nm.
  49. 1,2-O-Dihexadecyl-sn-glycerol
    1,2-O-Dihexadecyl-sn-glycerol is a saturated dialkyl glyceryl ether that can be used as a lipid anchor in the synthesis of synthetic glycolipids.
  50. Tricaprylin
    Tricaprylin
    Catalog Number 14549
    Tricaprylin is a triacylglycerol that induces nuclear edema and cytolysis in tumor cells.
  51. Triolein (18:1 TG)
    Triolein (18:1 TG)
    Catalog Number 14550
    Triolein is a triacylglycerol that inhibits oxidized LDL-induced decreases in cell viability and increases apoptosis in endotheial cells.
  52. 1,2,3-Tripalmitoyl-rac-glycerol
    1,2,3-Tripalmitoyl-rac-glycerol is a triacylglycerol that inhibits glucose-simulated insulin secretion.
  53. 1,2-Dimyristoyl-sn-glycero-3-PS (sodium salt)
    1,2-Dimyristoyl-sn-glycero-3-PS (sodium salt) is an anionic phospholipid used to formulate micelles and liposomes.
  54. 1-Palmitoyl-2-hydroxy-sn-glycero-3-PC
    1-Palmitoyl-2-hydroxy-sn-glycero-3-PC is a phospholipid that increases the production of ROS, decreases superoxide dimutase, and enhances neutrophil function.
  55. 1-Palmitoyl-sn-glycerol
    1-Palmitoyl-sn-glycerol
    Catalog Number 14556
    1-Palmitoyl-sn-glycerol is a monoacylglycerol that aids in the synthesis of glycerides and phospholipids.
  56. Monolaurin
    Monolaurin
    Catalog Number 14557
    Monolaurin is a monoacylglycerol that has antimicrobial and antibacterial properties
  57. Triheptanoin
    Triheptanoin
    Catalog Number 14558
    Triheptanoin is a triacylglycerol that is known to affect mitochondrial dyfunction.
  58. 1-Linoleoyl Glycerol
    1-Linoleoyl Glycerol
    Catalog Number 14559
    1-linoleoyl glycerol is a fatty acid glycerol that inhibits the enzyme platelet-activating factor (PAF) acetylhydrolase (AH)
  59. DMDAP
    DMDAP
    Catalog Number 26454
    Inquire for availability.
  60. DPDAP
    DPDAP
    Catalog Number 26455
  61. DSDAP
    DSDAP
    Catalog Number 26456
  62. Cholesterol (plant-based)
    Cholesterol (plant-based)
    Catalog Number 14565
    Inquire for availability.
  63. LipoVector™ Transfection Reagent
    LipoVector™ is our new lipid transfection reagent designed for the delivery of RNA, DNA, and proteins into eukaryotic cells (in vitro and in vivo). LipoVector™ interacts with nucleic acids and the cell membrane to provide efficient and safe delivery into cells. It can be used for transient and stable gene expression as well as co-transfections and is a powerful tool for intracellular delivery of nucleotides.
  64. LipoVector™ Transfection Reagent
    LipoVector™ Transfection Reagent
    Catalog Number 14494-100
    LipoVector™ is our new lipid transfection reagent designed for the delivery of RNA, DNA, and proteins into eukaryotic cells (in vitro and in vivo). Lipovector™ interacts with nucleic acids and the cell membrane to provide efficient and safe delivery into cells. It can be used for transient and stable gene expression as well as co-transfections and is a powerful tool for intracellular delivery of nucleotides.
  65. DOTAP Methyl Sulfate
    DOTAP Methyl Sulfate
    Catalog Number 14475MS
    DOTAP MS (N-[1-(2,3-Dioleoyloxy)propyl]-N,N,N-trimethylammonium methyl-sulfate) is a proven reagent for the highly efficient liposomal transfection of DNA, RNA, oligonucleotides, and some other negatively charged large biomolecules.
  66. Dimethyldipalmitylammonium
    Dimethyldipalmitylammonium
    Catalog Number 14544
    Dihexadecyldimethylammonium bromide is a cationic lipid used in combination with other lipids to formulate lipid nanoparticles.
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