Acridine mutagen ICR 191
Acridine Mutagen ICR 191 is a frameshift mutagenic standard for Ames test in Salmonella and E. Coli.
Synonyms: 6-Chloro-9-(3-[2-chloroethylamino]propylamino)-2-methoxyacridine dihydrochloride; ICR 191 diHCl; Ames mutagen 191; ICR 191 Acridine mutagen
Pietrzak, M., Halicka, H. D., Wieczorek, Z., Wieczorek, J. & Darzynkiewicz, Z. Attenuation of acridine mutagen ICR-191 — DNA interactions and DNA damage by the mutagen interceptor chlorophyllin. Biophysical Chemistry 135, 69–75 (2008). doi:10.1016/j.bpc.2008.03.004
Ames, B. N., Sims, P. & Grover, P. L. Epoxides of carcinogenic polycyclic hydrocarbons are frameshift mutagens. Science 176, 47–9 (1972). doi:10.1126/science.176.4030.47
Creech, H. J., Preston, R. K., Peck, R. M., O’Connell, A. P. & Ames, B. N. Antitumor and mutagenic properties of a variety of heterocyclic nitrogen and sulfur mustards. J med chem 15, 739–746 (1972). doi:10.1021/jm00277a011
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