trehalose 6,6'-dibehenate
C56H106O13
TDB is a glycolipid adjuvant and an immunomodulator that can induce a cell-mediated immune and antibody response. TDB, along with DDA, can be used to form non-phospholipid based liposomal-like nanoparticles. TDB also plays a critical role in stabilizing the nanoparticle membrane, especially during freeze-drying processes, by increasing the hydration of the membrane surface.
SYNONYMS: TDB, 22:0 Trehalose
Davidsen, Jesper, et al. "Characterization of cationic liposomes based on dimethyldioctadecylammonium and synthetic cord factor from M. tuberculosis (trehalose 6, 6′-dibehenate)—a novel adjuvant inducing both strong CMI and antibody responses." Biochimica et Biophysica Acta (BBA)-Biomembranes 1718.1-2 (2005): 22-31.